Chronicles the rise to power of a Catalan cardinal and his clan, who seek to establish a dynasty that would sway over the entire world and win him the ultimate prize, the Chair of Saint Peter.

After exacting vicious punishment on all those who opposed them, the Borgias are at the apex of their power and influence. With the world around them embroiled in war and turmoil, the original crime family will continue to exploit allies, silence critics, and solidify legacies. But this time, the seemingly unbreakable bonds of blood will be tested like never before, as the house notoriously united against the world becomes divided against itself.

The Borgia family becomes the most powerful and influential family of the Italian Renaissance when the patriarch Rodrigo Borgia becomes Pope Alexander VI.