Peter Parker, aka Spider-Man, battles the Sandman and Spidey's new symbiotic costume Venom, a jealous photographer, and Harry, who still blames him for his father's death, all the while trying to get engaged to MJ.

From Joss Whedon comes a new groundbreaking show. Echo is an "Active," an unwitting participant in the Dollhouse, an illegal underground organization that provides its elite clients with hired personas for various missions. Actives receive temporarily personality imprints to suit the client's needs. But now Echo is facing the FBI, her own shadowy past, and a rogue Active who wants to bring the Dollhouse down.